It depends on your requirements as different types of application are used in different ways. A purely advertising system is used very differently to a more general information system.
A requirement of a general information system might be to always show the date and time somewhere on the screen along with corporate branding and maybe a news feed.
If you only have a single zone screen you would have to add those items to every page you make which is time consuming. If you later want to alter your branding such as a logo or telephone number you would have to change all the pages with the wrong information in them.
With a multizone screen you can set aside some of the zones to show those corporate items and basically forget about them so your main pages just carry the information you want to show.
A multizone screen is in effect lots of individual signage screens all on one screen, so important information can be left on display all day long while other parts can show carousels of different information.
The image below of a six zone screen shows an example of this. The large zone is the primary content channel that you update regularly, while the smaller zones along the top and down one side show information that’s relatively static or auto updating.
The system offers many different predefined zone layouts so the above layout is one of many.
You can also create zone layouts in the page editor. This enables you to split the screen up any way you like, including putting smaller zones on top of bigger zones for great changing background effects.